Tirrell Group: Publications Latest

View All

  1. “Oligonucleotide-Peptide Complexes: Phase Control by Hybridization ,” Jeffrey R. Vieregg, Michael Lueckheide, Amanda B. Marciel, Lorraine Leon§, Alex J. Bologna†, Josean Reyes Rivera∥, and Matthew V. Tirrell*. J. Am. Chem. Soc., DOI: 10.1021/jacs.7b03567, 2018

  2. A zwitterionic block-copolymer, based on glutamic acid and lysine, reduces the biofouling of UF and RO membranes,” Maria Piatkovsky, Handan Acar, Amanda B. Marciel, Matthew Tirrell, Moshe Herzberg. Journal of Membrane Science, 549, 507-514, 2018


    In this study, the anti-fouling ability of coating ultrafiltration (UF) and reverse-osmosis (RO) membranes with a block copolymer of polystyrene (PS) bound to an alternating lysine–glutamic acid peptide PS-b-(KE)15) was analyzed. The PS-b-(KE)15 coating had no effect on membrane permeability. Membrane fouling experiments were conducted with extracellular polymeric substances (EPS) extracted from the biological sludge of a membrane bioreactor, which treats municipal wastewater. The mechanism responsible for the anti-fouling behavior, of the modified membranes, was found to be the hydration of the coating – attributed to the adsorption of electrolytes – as detected by quartz crystal microbalance with dissipation monitoring (QCM-D). The hydration of the coating was observed in the presence and absence of calcium. However, fouling of the modified membranes with EPS was mediated and enhanced by calcium, and the presence of calcium abolished the anti-fouling effects of the PS-b-(KE)15 layer on both UF and RO membranes. The interaction between EPS and the bare, uncoated membrane area in the presence of calcium likely eliminated the anti-fouling capabilities of the PS-b-(KE)15layer. Membrane coating may be further improved by designing a continuous, denser layer of PS-b-(KE)15.

  3. “Comparing Solvophobic and Multivalent Induced Collapse in Polyelectrolyte Brushes,” Nicholas E. Jackson, Blair K. Brettmann, Venkatram Vishwanath, Matthew Tirrell, and Juan J. de Pablo. ACS Macro Lett., 6, 155-160, 2017

  4. “Gel phase formation in dilute triblock copolyelectrolyte complexes,” S. Srivastava, M. Andreev, A. E. Levi, D. J. Goldfeld, J. Mao, W. T. Heller, V. M. Prabhu, J. J. De Pablo, M. Tirrell. Nature Commun., 8, 14131, 2017

  5. “Comparing solvophobic and multivalent induced collapse in polyelectrolyte brushes,” N. E. Jackson, B. K. Brettmann, V. Vishwanath, M. Tirrell, J. J. de Pablo. ACS Macro Letters, 6, 155, 2017

  6. “Lateral Structure Formation in Polyelectrolyte Brushes Induced by Multivalent Ions,” B. Brettmann, P. Pincus, M. Tirrell. Macromolecules, 50, 1225, 2017

  7. “Gadolinium-Functionalized Peptide Amphiphile Micelles for Multimodal Imaging of Atherosclerotic Lesions,” S. P. Yoo, F. Pineda, J. C. Barrett, C. Poon, M. Tirrell, E. J. Chung. ACS Omega, 1, 996, 2016

  8. “Directing the phase behavior of polyelectrolyte complexes using chiral patterned peptides,” N. M. Pacalin, L. Leon, M. Tirrell. The European Physical Journal Special Topics, 225, 1805, 2016

  9. “Polyelectrolyte Complexation,” S. Srivastava and M. Tirrell. Advances in Chemical Physics, 161, 499-544, 2016

  10. “Modular Peptide Amphiphile Micelles Improving an Antibody-Mediated Immune Response to Group A Streptococcus,” J. C. Barrett, B. D. Ulery, A. Trent, S. Liang, N. A. David, and M. Tirrell. ACS Biomaterials Science & Engineering, 2016

  11. “Self-assembling peptide-based building blocks in medical applications,” H. Acar, S. Srivastava, E. J. Chung, M. R. Schnorenberg, J. C. Barrett, J. L. LaBelle, M. Tirrell. Advanced Drug Delivery Reviews, 2016

  12. “Structure of polyelectrolyte brushes in the presence of multivalent counterions,” J.Yu, J. Mao, G.C. Yuan, S, Satija, Z. Jiang, W. Chen, and M. Tirrell. Macromolecules, 49, 5609-5617, 2016

  13. “The effect of multivalent counterions on the structure of highly dense poly styrene sulfonate brushes,” J. Yu, J. Mao, G.C. Yuan, S. Satija, W. Chen and M. Tirrell. Polymer, 98, 448-453, 2016

  14. “Adhesion and Detachment Mechanisms between Polymer and Solid Substrate Surfaces: Using Polystyrene–Mica as a Model System,” H. Zeng, J. Huang, Y. Tian, L. Li, M. V. Tirrell, J. N. Israelachvili. Macromolecules, 49, 5223, 2016

  15. “Bridging contributions to polyelectrolyte brush collapse in multivalent salt solutions,” B.K. Brettmann, P. Hoffman, P. Pincus and M. Tirrell. J. Polymer Sci., Part A, Polymer Chemistry, 54, 184-291, 2016

Socialize With Us