Tirrell Group: Publications Latest

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  1. “Synthesis and Purification of Homogeneous Lipid-Based Peptide Nanocarriers by Overcoming Phospholipid Ester Hydrolysis,” Schnorenberg, M. R., Yoo, S. P., Tirrell, M. V., LaBelle. ACS Omega, 3, 14144-14150, 2018

  2. “Polyelectrolyte complexation of oligonucleotides by charged hydrophobic–neutral hydrophilic block copolymers,” Marras, A. E., Vieregg, J. R., Ting, J. M., Rubien, J. D., Tirrell, M. V.. Polymers, 11, 83, 2019

  3. “Structure-property relationships of oligonucleotide polyelectrolyte complex micelles,” M. Lueckheide], J.R. Vieregg, A.J. Bologna, and M.V. Tirrell. Nano Letters ,

  4. “Inhibiting sterilization-induced oxidation of large molecule therapeutics packaged in plastic parenteral vials,” J.R. Vieregg, S.J. Martin, A.P. Breeland, C.M. Weikart, and M.V. Tirrell. PDA J. Pharm. Sci. Tech., 72, 35-43, 2017

  5. Non-equilibrium phenomena and kinetic pathways in self-assembled polyelectrolyte complexes,” Hao Wu, Jeffrey M. Ting, Olivia Werba, Matthew V. Tirrell. Journal of Chemical Physics , 149, 163330, 2018

  6. “Multivalent counterions diminish the lubricity of polyelectrolyte brushes,” J. Yu, N. E. Jackson, X. Xu, Y. Morgenstern, Y. Kaufman, M. Ruths, J. J. de Pablo, M. Tirrell. Science , 360, 1434-1438, 2018

  7. “Synthesis and Assembly of Designer Styrenic Diblock Polyelectrolytes,” Jeffrey M. Ting, Hao Wu, Abraham Herzog-Arbeitman, Samanvaya Srivastava, Matthew V. Tirrell. ACS Macro Letters, 7, 726-733, 2018

  8. “Phase Behavior and Salt Partitioning in Polyelectrolyte Complex Coacervates,” L. Li, S. Srivastava, M. Andreev, A. Marciel, J.de Pablo, M. V. Tirrell. Macromolecules, 51, 2988–2995, 2018

  9. Structure and Rheology of Polyelectrolyte Complex Coacervates ,” Amanda B. Marciel, Samanvaya Srivastava, Matthew V. Tirrell . Soft Matter , 14, 2454-2464 , 2018

  10. “Multivalent ions induce lateral structural inhomogeneities in polyelectrolyte brushes ,” Jing Yu, Nicholas E. Jackson, Xin Xu, Blair K. Brettmann, Marina Ruths, Juan J. de Pablo, Matthew Tirrell. Science Advances , 3, 2017

  11. “Gel phase formation in dilute triblock copolyelectrolyte complexes,” Samanvaya Srivastava, Marat Andreev, Adam E. Levi, David J. Goldfeld, Jun Mao, William T. Heller, Vivek M. Prabhu, Juan J. de Pablo, Matthew V. Tirrell. Nature Communications, 8, 2017

  12. Open-to-Air RAFT Polymerization in Complex Solvents: From Whisky to Fermentation Broth,” Deborah K. Schneiderman, Jeffrey M. Ting , Anatolii A. Purchel, Ron Miranda, Jr., Matthew V. Tirrell, Theresa M. Reineke, and Stuart J. Rowan. ACS Macro Letters, 7, 406-411, 2018


    in situ enzyme degassing to facilitate open-to-air RAFT polymerization of hydroxyethyl acrylate in beer, wine, liquor, and fermentation broth.

  13. “Oligonucleotide-Peptide Complexes: Phase Control by Hybridization ,” Jeffrey R. Vieregg, Michael Lueckheide, Amanda B. Marciel, Lorraine Leon§, Alex J. Bologna†, Josean Reyes Rivera∥, and Matthew V. Tirrell*. J. Am. Chem. Soc., DOI: 10.1021/jacs.7b03567, 2018

  14. A zwitterionic block-copolymer, based on glutamic acid and lysine, reduces the biofouling of UF and RO membranes,” Maria Piatkovsky, Handan Acar, Amanda B. Marciel, Matthew Tirrell, Moshe Herzberg. Journal of Membrane Science, 549, 507-514, 2018


    In this study, the anti-fouling ability of coating ultrafiltration (UF) and reverse-osmosis (RO) membranes with a block copolymer of polystyrene (PS) bound to an alternating lysine–glutamic acid peptide PS-b-(KE)15) was analyzed. The PS-b-(KE)15 coating had no effect on membrane permeability. Membrane fouling experiments were conducted with extracellular polymeric substances (EPS) extracted from the biological sludge of a membrane bioreactor, which treats municipal wastewater. The mechanism responsible for the anti-fouling behavior, of the modified membranes, was found to be the hydration of the coating – attributed to the adsorption of electrolytes – as detected by quartz crystal microbalance with dissipation monitoring (QCM-D). The hydration of the coating was observed in the presence and absence of calcium. However, fouling of the modified membranes with EPS was mediated and enhanced by calcium, and the presence of calcium abolished the anti-fouling effects of the PS-b-(KE)15 layer on both UF and RO membranes. The interaction between EPS and the bare, uncoated membrane area in the presence of calcium likely eliminated the anti-fouling capabilities of the PS-b-(KE)15layer. Membrane coating may be further improved by designing a continuous, denser layer of PS-b-(KE)15.

  15. “Comparing Solvophobic and Multivalent Induced Collapse in Polyelectrolyte Brushes,” Nicholas E. Jackson, Blair K. Brettmann, Venkatram Vishwanath, Matthew Tirrell, and Juan J. de Pablo. ACS Macro Lett., 6, 155-160, 2017

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