Publications

  • Esser-Kahn Group
    “Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters),” Sampa Maiti, Saikat Manna, Jingjing Shen, Aaron P. Esser-Kahn, and Wenjun Du. Journal of the American Chemical Society, 2019

  • Awschalom Group, Cleland Group, Galli Group
    “Spin-phonon interactions in silicon carbide addressed by Gaussian acoustics,” S. J. Whiteley, G. Wolfowicz, C. P. Anderson, A. Bourassa, H. Ma, M. Ye, G. Koolstra, K. J. Satzinger, M. V. Holt, F. J. Heremans, A. N. Cleland, D. I. Schuster, G. Galli, D. D. Awschalom. Nature Physics, advance online publication, 2019

  • Skinner Group
    “Mid-IR spectroscopy of supercritical water: From dilute gas to dense fluid,” Nicholas J. Hestand, Steven E. Strong, Liang Shi, and J. L. Skinner. J. Chem. Phys., 150, 054505, 2019

  • Esser-Kahn Group
    Immune potentiator for increased safety and improved protection of vaccines by NF-kB modulation,” Brittany A Moser, Rachel C Steinhardt, Yoseline Escalante-Buendia, David A Bolt, Kaylynn M Barker, Stan Yoo, Bethany G McGonnigal, Aaron P Esser-Kahn. bioRxiv,

    Overview

    Many modern vaccines include adjuvants that activate the immune system and provide an enhanced humoral or cellular response. Current approved adjuvants are unable to provide desired responses against some pathogens (e.g. HIV or dengue). Many new adjuvants have been developed and demonstrate promising results, but side effects from the inflammatory response induced by these adjuvants have resulted in limited FDA approvals. No adjuvants yet possess the capability to independently modulate inflammation and protection. Here we demonstrate a method to limit inflammation and side effects associated with vaccination while retaining the protective responses using a variety of promising adjuvants. To accomplish this, we combined a selective NF-kB inhibitor with the immune adjuvant. The resulting vaccines reduce systemic inflammation and boost antibody responses. In an influenza challenge model, we demonstrate that this approach enhances protection. This method is generalizable across a broad range of adjuvants and antigens. We anticipate these studies will lead to a novel approach to vaccine formulation design that may prove general across a wide range of adjuvants, enabling their greater use in the public realm.

  • Cleland Group, Awschalom Group
    “Quantum control of surface acoustic-wave phonons,” K. J. Satzinger, Y. P. Zhong, H.-S. Chang, G. A. Peairs, A. Bienfait, M.-H. Chou, A. Y. Cleland, C. R. Conner, E. Dumur, J. Grebel, I. Gutierrez, B. H. November, R. G. Povey, S. J. Whiteley, D. D. Awschalom, D. I. Schuster, A. N. Cleland. Nature, 563, 661-665, 2018

  • Esser-Kahn Group
    Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development,” Janine K. Tom, Tyler J. Albin, Saikat Manna, Brittany A. Moser, Rachel C. Steinhardt, Aaron P. Esser-Kahn. Trends in Biotechnology,

    Overview

    Vaccines are some of the most successful therapies available to prevent infection. Immune synergies are being applied as tools for novel adjuvant design to improve vaccine efficacy. Next-generation synergistic adjuvants are being developed because many current adjuvants suffer from systemic toxicity or low potency.

    Novel technologies are being developed that examine synergistic interactions and enhance adjuvanticity to develop more potent and effective adjuvants. New approaches, including high-throughput screening, can provide more rapid analyses, dose sparing, and targeted delivery of vaccines.

    Targeting specific cellular compartments and cell subsets with adjuvants are emerging as ways to provide more directed immune responses. In addition, controlling the kinetic profile and robustness of the immune response has been shown to be an important factor for synergistic vaccine efficacy.

  • Awschalom Group
    “Atomic layer deposition of titanium nitride for quantum circuits,” (Featured on cover) A. Shearrow, G. Koolstra, S. J. Whiteley, N. Earnest, P. S. Barry, F. J. Heremans, D. D. Awschalom, E. Shirokoff, D. I. Schuster. Appl. Phys. Lett., 113, 212601, 2018

  • Skinner Group
    “Perspective: Crossing the Widom line in no man’s land: Experiments, simulations, and the location of the liquid-liquid critical point in supercooled water,” Nicholas J. Hestand and J. L. Skinner. J. Chem. Phys., 149, 140901, 2018

  • Awschalom Group
    “National Science Foundation-Sponsored Workshop Report on Midscale Instrumentation to Accelerate Progress in Quantum Materials,” Collin Broholm, David D. Awschalom, Daniel S. Dessau, and Laura H. Greene, September 2018. Available at

  • Rowan Group
    Strong, Rebondable, Dynamic Cross-Linked Cellulose Nanocrystal Polymer Nanocomposite Adhesives,” Elvis Cudjoe, Katie M. Herbert, and Stuart J. Rowan. ACS Applied Materials and Interfaces, 2018

    Overview

    Nanocomposite adhesive films have been prepared via the oxidation of a thiol-endcapped semicrystalline oligomer with varying amounts of thiol-functionalized CNCs. Stronger substrate-bonding was achieved at temperatures where the disulfide bonds are dynamic. The 30 wt % nanocomposite adhesive was compared to some common commercially available adhesives and showed significantly stronger shear strengths when bonded to metal.

  • Skinner Group
    “Percolation in supercritical water: Do the Widom and percolation lines coincide?,” S. E. Strong, L. Shi, and J. L. Skinner. J. Chem. Phys., 149 (8), 084504, 2018

  • Awschalom Group
    “Strain annealing of SiC nanoparticles revealed through Bragg coherent diffraction imaging for quantum technologies,” S. O. Hruszkewycz, S. Maddali, C. P. Anderson, W. Cha, K. C. Miao, M. J. Highland, A. Ulvestad, D. D. Awschalom, F. J. Heremans. Phys. Rev. Materials, 2, 086001, 2018

  • de Pablo Group, Rowan Group
    Topological Effects in Isolated Poly[n]catenanes: Molecular Dynamics Simulations and Rouse Mode Analysis,” P.M. Rauscher, S.J. Rowan, JJ de Pablo. ACS Macro Letters, 7, 938-943, 2018

    Overview

    Molecular dynamics simulations of isolated poly[n]catenanes have been conducted, along with a Rouse mode analysis. At large length scales poly[n]catenanes do not relax much slower than isolated linear polymers and are less strongly impacted by increased segmental stiffness.

  • Awschalom Group
    “Electrometry by optical charge conversion of deep defects in 4H-SiC,” G. Wolfowicz, S. J. Whiteley, D.D. Awschalom. Proc. Natl. Acad. Sci., 201806998, 2018

  • Awschalom Group, Nealey Group
    “Microscale resolution thermal mapping using a flexible platform of patterned quantum sensors,” P. Andrich, J. Li, X. Liu, F. J. Heremans, P. F. Nealey, D. D. Awschalom. Nano Lett., 2018

  • Skinner Group
    “Fermi resonance in OH-stretch vibrational spectroscopy of liquid water and the water hexamer,” Alexei A. Kananenka and J. L. Skinner. J. Chem. Phys., 148, 244107, 2018

  • Esser-Kahn Group
    “Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional Regulation via Lysosomal Rupture,” Saikat Manna, William J. Howitz, Nathan J. Oldenhuis, Alexander C. Eldredge, Jingjing Shen, Fnu Naorem Nihesh, Melissa B. Lodoen, Zhibin Guan , and Aaron P. Esser-Kahn. ACS Central Science, 4 (8), 982-995, 2018

  • Galli Group
    First-Principles Simulations of Liquid Water Using a Dielectric-Dependent Hybrid Functional,” Alex Gaiduk, Jeffrey Gustafson, Francois Gygi, and Giulia Galli. J. Phys. Chem. Lett., 9, 3068-3073, 2018

  • de Pablo Group, Galli Group
    Hierarchical Coupling of First Principles Molecular Dynamics with Advanced Sampling Methods,” Emre Sevgen, Federico Giberti, Hythem Sidky, Jonathan Whitmer, Giulia Galli, Francois Gygi, and Juan de Pablo. J. Chem. Theory Comput., 14, 6, 2018

  • Galli Group
    GW100: Comparison of methods and accuracy of results obtained with the WEST code,” Marco Govoni and Giulia Galli. J. Chem. Theory. Comp., 14, 1895-1909, 2018

  • Skinner Group
    “Communication: Diffusion constant in supercooled water as the Widom line is crossed in no man’s land,” Yicun Ni, Nicholas J. Hestand, and J. L. Skinner. J. Chem. Phys., 148, 191102, 2018

  • Tirrell Group
    Structure and Rheology of Polyelectrolyte Complex Coacervates ,” Amanda B. Marciel, Samanvaya Srivastava, Matthew V. Tirrell . Soft Matter , 14, 2454-2464 , 2018

  • de Pablo Group
    “Dynamic actuation of glassy polymersomes through isomerization of a single azobenzene unit at the block copolymer interface,” Mijanur Rahaman Molla, Poornima Rangadurai, Lucas Antony, Subramani Swaminathan, Juan J. de Pablo & S. Thayumanavan. Nature Chemistry, 2018

  • Skinner Group
    “Second-Order Vibrational Lineshapes from the Air/Water Interface,” Paul E. Ohno, Hong-fei Wang, Francesco Paesani, J. L. Skinner, and Franz M. Geiger. J. Phys. Chem. A, 122, 4457-4464, 2018

  • de Pablo Group
    “Light-activated helical inversion in cholesteric liquid crystal microdroplets,” Piotr Sleczkowski, Ye Zhou, Supitchaya Iamsaard, Juan J. de Pablo, Nathalie Katsonis and Emmanuelle Lacaze. PNAS, 201720742, 2018

  • Awschalom Group
    “Opportunities for Basic Research for Next-Generation Quantum Systems,” David Awschalom and Hans Christen, Chairs, Department of Energy, Office of Basic Energy Sciences, 2018. Available at

  • Rowan Group, Tirrell Group
    Open-to-Air RAFT Polymerization in Complex Solvents: From Whisky to Fermentation Broth,” Deborah K. Schneiderman, Jeffrey M. Ting , Anatolii A. Purchel, Ron Miranda, Jr., Matthew V. Tirrell, Theresa M. Reineke, and Stuart J. Rowan. ACS Macro Letters, 7, 406-411, 2018

    Overview

    in situ enzyme degassing to facilitate open-to-air RAFT polymerization of hydroxyethyl acrylate in beer, wine, liquor, and fermentation broth.

  • Galli Group
    Sterically controlled mechanochemistry under hydrostatic pressure,” Hao Yan, Fan Yang, Ding Pan, Yu Lin, J. Nathan Hohman, Diego Solis-Ibarra, Fei Hua Li, Jeremy E. P. Dahl, Robert M. K. Carlson, Boryslav A. Tkachenko, Andrey A. Fokin, Peter R. Schreiner, Giulia Galli, Wendy L. Mao, Zhi-Xun Shen & Nicholas A. Melosh. Nature, 554, 505-510, 2018

  • Esser-Kahn Group
    “Bio-inspired counter-current multiplier for enrichment of solutes,” Kyle Brubaker, Armand Garewal, Rachel C. Steinhardt & Aaron P. Esser-Kahn. Nature Communications, 9, 2018

  • de Pablo Group
    “Auxetic metamaterials from disordered networks,” Daniel R. Reid, Nidhi Pashine, Justin M. Wozniak, Heinrich M. Jaeger, Andrea J. Liu, Sidney R. Nagel and Juan J. de Pablo. PNAS, 115, 2018

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