Director, Institute for Genomics & Systems Biology; Professor, Department of Human Genetics
900 E. 57th St.
Chicago, IL 60637
kpwhite at uchicago.edu
Mapping the regulatory wiring diagrams encoded in genomes is key to understanding development, disease, and evolution. The White lab studies the coordinated action of networks of genes that control developmental and evolutionary processes. We have particular focus on building genome-wide models of transcriptional networks, and we use an integrated approach that makes use of gene expression microarrays, large-scale protein-protein and protein-DNA interaction analyses, systematic RNAi analysis and high throughput polymorphism detection.
By applying our methods to both closely and distantly related species, we are investigating how conserved molecular networks control basic developmental processes and how variation in molecular networks translates into variation in organismal phenotypes. We are particularly interested in the transcriptional networks controlled by nuclear receptor proteins in development and disease. We also are studying the transcriptional mechanisms involved in patterning early embryos. We make use of the compact Drosophila genome and the genomes of related species as model systems for many of our studies, and recently we have also begun to apply these genomics and computational approaches to investigations of the human genome
Dr. White graduated magna cum laude from Yale University with a joint BS-MS degree in biology in 1993. He completed his PhD in developmental biology at Stanford University in 1998, followed by a postdoctoral fellowship in biochemistry and genomics at the Stanford Genome Technology Center. In 2001, he joined the faculty at Yale University as an Assistant Professor of Genetics, and was promoted to Associate Professor in 2003.
He was named an NIH Genome Scholar in 2000, a W.M. Keck Distinguished Young Investigator in Medical Sciences in 2003, an Arnold and Mabel Beckman Young Investigator in 2004, a Pritzker Fellow in 2006, and James and Karen Frank Family Professor in 2006. In 2004, he was elected chairman of the Gordon Conference on Genomics, and in 2005, vice-chairman of the Gordon Conference on Hormone Action in Development and Cancer.