Event: IME Seminar: Juan Mendoza

Date

January 16, 2018
1:00 PM - 2:00 PM

Location

ERC 161

Details

Speaker: Juan Mendoza
Postdoctoral Fellow, Department of Molecular & Cellular Physiology
Stanford University

Title: "Enhancing the therapeutic potential of cytokines through protein engineering"

The interferon (IFN) superfamily of cytokines are an essential part of the innate immune system providing protection against the spread of viral infections and cancerous growths. There are three families of IFNs, type I-III, each with distinct ligand-receptor systems. This presentation will report on efforts to elucidate the structure-functional relationships of IFN induced signaling and to enhance IFN functions. For these efforts, a protein engineering approach has been applied to rapidly evolve IFNs and visualize the three-dimensional shapes of interferon cytokines bound to their cellular receptors. These results provide new insight to cytokine signaling and new opportunities for developing promising molecules for basic research and clinical use.The interferon (IFN) superfamily of cytokines are an essential part of the innate immune system providing protection against the spread of viral infections and cancerous growths. There are three families of IFNs, type I-III, each with distinct ligand-receptor systems. This presentation will report on efforts to elucidate the structure-functional relationships of IFN induced signaling and to enhance IFN functions. For these efforts, a protein engineering approach has been applied to rapidly evolve IFNs and visualize the three-dimensional shapes of interferon cytokines bound to their cellular receptors. These results provide new insight to cytokine signaling and new opportunities for developing promising molecules for basic research and clinical use.

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