Ashley is from Cary, North Carolina. In 2014, she graduated from Caltech with a BS in chemical engineering. She then joined the inaugural class of PhD students in the Institute for Molecular Engineering (now the Pritzker School of Molecular Engineering) at the University of Chicago. Ashley is now a graduate student in Professor Juan de Pablo's group, working on molecular simulations of protein aggregation and liquid crystal sensing applications. In addition to research, Ashley enjoys biking, learning foreign languages, and pushing the limits of apartment gardening.
The aggregation of proteins into amyloid fibrils is implicated in numerous chronic diseases affecting millions of people worldwide. These illnesses include Alzheimer’s disease, Parkinson’s disease, and type II diabetes. It is now understood that early-stage aggregates are toxic, prompting a shift from studying mature fibrils to investigating mechanisms of nascent fibril formation and related intermediates. However, there are still challenges in identifying aggregation pathways and detecting early-stage aggregates. Ashley's research addresses these challenges on two fronts: (1) investigating the mechanism behind early-stage amyloid aggregates using molecular simulations, specifically with molecular dynamics and the string method sampling technique, and (2) detecting early-stage amyloid aggregates with liquid crystals.
Harnessing Peptide Binding to Capture and Reclaim Phosphate
Fowler, Whitney C., et al. "Harnessing Peptide Binding to Capture and Reclaim Phosphate." Journal of the American Chemical Society 143.11 (2021): 4440-4450. Whitney C. Fowler, Chuting Deng, Gabriella M. Griffen, Tess Teodoro, Ashley Z. Guo, Michal Zaiden, Moshe Gottlieb*, Juan J. de Pablo, Matthew V. Tirrell
Harnessing Peptide Binding to Capture and Reclaim Phosphate
Whitney C Fowler, Chuting Deng, Gabriella M Griffen, Tess Teodoro, Ashley Z Guo, Michal Zaiden, Moshe Gottlieb, Juan J de Pablo, Matthew V Tirrell. "Harnessing Peptide Binding to Capture and Reclaim Phosphate", Journal of the American Chemical Society, 2021.
Free energy of metal-organic framework self-assembly
Colón, Yamil J., et al. "Free energy of metal-organic framework self-assembly." The Journal of chemical physics 150.10 (2019): 104502.
Extracting collective motions underlying nucleosome dynamics via nonlinear manifold learning
Guo, Ashley Z., Joshua Lequieu, and Juan J. de Pablo. "Extracting collective motions underlying nucleosome dynamics via nonlinear manifold learning." The Journal of chemical physics 150.5 (2019): 054902.
Early-stage human islet amyloid polypeptide aggregation: Mechanisms behind dimer formation
Guo, Ashley Z., Aaron M. Fluitt, and Juan J. de Pablo. "Early-stage human islet amyloid polypeptide aggregation: Mechanisms behind dimer formation." The Journal of chemical physics 149.2 (2018): 025101.
Adaptive enhanced sampling by force-biasing using neural networks
Guo, Ashley Z., et al. "Adaptive enhanced sampling by force-biasing using neural networks." The Journal of chemical physics 148.13 (2018): 134108.
Ssages: Software suite for advanced general ensemble simulations
Sidky, Hythem, et al. "Ssages: Software suite for advanced general ensemble simulations." The Journal of chemical physics 148.4 (2018): 044104.
Spherical nematic shells with a prolate ellipsoidal core
Sadati, Monirosadat, et al. "Spherical nematic shells with a prolate ellipsoidal core." Soft matter 13.41 (2017): 7465-7472.
Mesoscale structure of chiral nematic shells
Zhou, Ye, et al. "Mesoscale structure of chiral nematic shells." Soft matter 12.44 (2016): 8983-8989.